BP204T. PATHOPHYSIOLOGY (THEORY)

B. Pharm. 1st Year (2nd Sem.)

Unit I 10Hours  Basic principles of Cell injury and Adaptation:
Introduction, definitions, Homeostasis, Components and Types of Feedback systems,
Causes of cellular injury,Pathogenesis (Cell membrane damage, Mitochondrial damage,
Ribosome damage, Nuclear damage),Morphology of cell injury – Adaptive changes
(Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia),Cell swelling, Intra cellular
accumulation, Calcification, Enzyme leakage and Cell Death Acidosis
&Alkalosis,Electrolyte imbalance
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 Basic mechanism involved in the process of inflammation and repair:
Introduction, Clinical signs of inflammation, Different types of Inflammation,Mechanism
of Inflammation – Alteration in vascular permeability and blood flow, migration of
WBC’s,Mediators of inflammation,Basic principles of wound healing in the
skin,Pathophysiology of Atherosclerosis
Unit II 10Hours  Cardiovascular System:
Hypertension, congestive heart failure, ischemic heart disease (angina,myocardial
infarction, atherosclerosis and arteriosclerosis)  Respiratory system:Asthma, Chronic obstructive airways diseases.  Renal system:Acute and chronic renal failure . Unit II 10Hours  Haematological Diseases:
Iron deficiency, megaloblastic anemia (Vit B12 and folic acid), sickle cell anemia, thalasemia, hereditary acquired anemia, hemophilia  Endocrine system: Diabetes, thyroid diseases, disorders of sex hormones  Nervous system: Epilepsy, Parkinson’s disease, stroke, psychiatric disorders:
depression, schizophrenia and Alzheimer’s disease.  Gastrointestinal system: Peptic Ulcer  Unit IV 8 Hours  Inflammatory bowel diseases, jaundice, hepatitis (A,B,C,D,E,F) alcoholic liver
disease.  Disease of bones and joints: Rheumatoid arthritis, osteoporosis and gout  Principles of cancer: classification, etiology and pathogenesis of cancer  Diseases of bones and joints:Rheumatoid Arthritis, Osteoporosis,Gout  Principles of Cancer: Classification, etiology and pathogenesis of Cancer
Unit V 7 Hours  Infectious diseases:Meningitis,Typhoid, Leprosy, Tuberculosis
Urinary tract infections  Sexually transmitted diseases:AIDS, Syphilis, Gonorrhea